Research NanoFuse | KIC Ventures

NanoFuse Research

Featured Study

Comparative Osteoinductive Potential of BMP-2, Bioactive Glass, and Demineralized Bone Matrix: An In Vitro Alkaline Phosphatase Assay Study

Kingsley R Chin 1, Chukwunonso C Ilogu, Sukanya Chebrolu, William M Costigan, Erik Spayde, Vito Lore, Douglas P Beall, Robby Lane, Josue P Gabriel, Aditya Humad, Jason A Seale.

This in vitro study compared the osteoinductive potential of recombinant BMP-2, bioactive glass (BAG), demineralized bone matrix (DBM), and a composite nano-BAG + DBM formulation (NanoFuse DBM) using a C2C12 alkaline phosphatase assay. Results demonstrated that wet/frozen DBM produced the highest alkaline phosphatase activity, while NanoFuse DBM at higher concentration exceeded the assay’s detection limit and outperformed BMP-2, DBM + gel, and BAG-based formulations. BMP-2 showed comparatively lower osteogenic activity at the tested dose, and BAG alone exhibited minimal induction. Overall, the findings suggest that NanoFuse DBM provides robust, dose-dependent osteoinductive activity and may represent a safer and more effective alternative to BMP-2 and traditional graft materials for spinal fusion and other orthopedic applications, warranting further in vivo investigation.

View PDF

Pending Publication

Efficacy of an FDA Approved Synthetic Nano-Bioactive Glass Plus Demineralized Bone Matrix (DBM) Combination versus DBM Alone in Instrumented Lumbar Fusion for Low-Grade Degenerative Spondylolisthesis: A Prospective Randomized Controlled Trial Pilot Study

Pending Publication

A Prospective Randomized Controlled Trial Comparing Nano-Bioactive Glass plus Demineralized Bone Matrix (DBM) vs. DBM Alone in Single-Level ACDF with Standalone PEEK Cages

Pending Publication

An In Vitro Study of Alkaline Phosphatase Induction as a Quantitative Measure of the Osteoinductive Potential of FDA-Approved Nano-Bioactive Glass Combined with Demineralized Bone Matrix (DBM) vs Bioactive Glass Alone and DBM Alone

Pending Publication

Safety and efficacy of a nano-bioactive glass combined with demineralized bone matrix (DBM) versus DBM alone with standalone PEEK cages in two-level ACDF: A prospective randomized controlled trial pilot study

NanoFuse Biologics Bioglass Studies

Int J Spine Surg . 2025 Dec 28;19(6)

Comparative Osteoinductive Potential of BMP-2, Bioactive Glass, and Demineralized Bone Matrix: An In Vitro Alkaline Phosphatase Assay Study

Kingsley R Chin 1, Chukwunonso C Ilogu, Sukanya Chebrolu, William M Costigan, Erik Spayde, Vito Lore, Douglas P Beall, Robby Lane, Josue P Gabriel, Aditya Humad, Jason A Seale

View PDF

Cell Tissue Bank. 2013 Mar;14(1)

Osteoconductivity and osteoinductivity of NanoFUSE(®) DBM

James F Kirk 1, Gregg Ritter, Chad Waters, Sonoko Narisawa, José Luis Millán, James D Talton

View PDF

International Journal of Biomedical Materials Research. 2015 July;3(3)

Radiographic, Histologic and Mechanical Comparison of NanoFUSE® DBM and a Bioactive Glass in a Rabbit Spinal Fusion Model

James F. Kirk, Gregg Ritter, Michael J. Larson, Robert C. Waters, Isaac finger, John Waters, John H. Abernethy, Dhyana Sankar, James D. Talton, Ronald R. Cobb

View PDF

Acta Biomater. 2011 Jun;7(6)

Bioactive glass in tissue engineering

Mohamed N Rahaman 1, Delbert E Day, B Sonny Bal, Qiang Fu, Steven B Jung, Lynda F Bonewald, Antoni P Tomsia

View PDF

Nanomaterials (Basel). 2024 Jul 13;14(14):1196.

Current and Future Perspectives of Bioactive Glasses as Injectable Material

Andreea-Luiza Mîrț, Denisa Ficai, Ovidiu-Cristian Oprea, Gabriel Vasilievici, Anton Ficai

View PDF

Cureus. 2021 Jul 15;13(7)

CT Scan and Clinical Outcomes of Novel Lateral-Oblique Percutaneous Sacroiliac Joint (SIJ) Fixation: Technique and Literature Review

Kingsley R Chin , Fabio J Pencle, Jason A Seale, Deepak K Pandey